A New Mechanism of Non-Hormonal Contraception using Mucoadhesive Polymers
Effective family planning is critical for women’s empowerment and improvement in child and maternal health, yet nearly half of the world’s pregnancies are unintended(1), representing a clear unmet need for contraception. Hormonal contraceptive regimens offer high efficacy but may induce a systemic side effect profile that reduces compliance. New research into contraceptive development has stagnated since the 1980s, due to the exit of the U.S. pharmaceutical industry from the arena. Consequently, existing pericoital non-hormonal contraceptives, such as spermicides and gels, are unsatisfactory, suffering from high failure rates in typical use as well as high discontinuation rates, which partially stem from vaginal irritation and discomfort. To solve these issues, Schimpf and colleagues, reporting in Science Translational Medicine(2), proposed a novel mechanism that could represent the next generation in contraceptive design. They developed a formulation of chitosan mucoadhesive polymers that can be topically applied to physically reinforce the cervical mucus barrier against sperm penetration. Their vaginal gel formulation decreased average uterine sperm...