The 2017 Mexico City Policy, or Global Gag Rule, prohibits non-US-based NGOs from receiving US global health assistance if they either perform or refer for abortion services. Sherwood et al. (2020) studied the effects of the expanded policy on implementing partners of US-funded HIV programming by the President’s Emergency Plan for AIDS Relief (PEPFAR) via a survey in all recipient countries. Survey results showed that 28% of organizations reported stopping or reducing at least one service in response to the policy. The delivery of information about sexual and reproductive health, pregnancy counseling, contraceptive provision, and HIV testing were services reduced. These disproportionately harmed pregnant women, youth and vulnerable populations such as sex workers and men who have sex with men. Thus, the intended beneficiaries of PEPFAR funding may be the most negatively impacted, especially in areas with high HIV prevalence. This study calls attention to policy makers to respond to disruptions in service delivery from the expanded Mexico City Policy in the formulation of global health policy.